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Genetic Analysis: An Integrated Approach

Mark F. Sanders, University of California at Davis

John L. Bowman, Monash University

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ISBN-13:	9780321732507
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Overview

Description

Informed by many years of genetics teaching and research experience, authors Mark Sanders and John Bowman use an integrative approach that helps contextualize three core challenges of learning genetics: solving problems, understanding evolution, and understanding the connection between traditional genetics models and more modern approaches.

This package contains:

Genetic Analysis: An Integrated Approach

Features

An integrative problem-solving approach presents a consistent and effective strategy for students to work through genetics problems.

Genetic Analysis sections guide students with a unique, three step approach that trains them to Evaluate, Deduce, and then Solve problems. Each Genetic Analysis is presented in a clear, two-column format that helps students see the Solution Strategy in one column and its corresponding execution in the Solution Step. Genetic Analysis sections are integrated throughout each chapter, right after discussions of important content. Each one includes helpful Tips to highlight critical steps and Pitfalls to avoid, as well as references to similar problems at the end of the chapter for additional practice.
End-of-Chapter Problems are divided into separate sections labeled Chapter Concepts and Application and Integration. The book offers a broad range of question types and level of difficulty. Answers to even-numbered problems appear in the Appendix.
The Accompanying Student Solutions Manual and Study Guide provides additional worked problems along with tips for solving problems. It also presents solutions to all of the textbook problems in a consistent Evaluate, Deduce, and Solve format to complement the approach modeled in the Genetic Analysis examples.

Thorough coverage of Experiments and Research Techniques engages students in the process of science and subsequent genetics discoveries.

Experimental Insight essays discuss influential experiments, summarize real experimental data derived from the experiments, and explain conclusions drawn from the analysis of results.
Research Technique boxes explore important research methods and visually illustrate the results and interpretations of the techniques.
Unique Chapter 10: The Integration of Genetic Approaches integrates transmission genetics, molecular analysis, molecular techniques, and evolution in an exploration of sickle cell disease.
Case Studies are short, real-world examples that appear at the end of every chapter and highlight central ideas or concepts of the chapter with interesting examples that remind students of some practical applications of genetics.

Carefully crafted summaries and figures help students distill the most important “take home” lessons in each chapter.

Genetic Insights appear several times within each chapter and help students recognize and understand key concepts at-a-glance.
Foundation Figures integrate text and art to illustrate pivotal genetics concepts in a concise, easy-to-follow format.

An integrative evolutionary perspective is demonstrated throughout the book, helping students keep sight of important evolutionary principles as they are learning the core genetics concepts. Examples include a discussion of sickle cell evolution in Chapter 10 and evolutionary questions presented by the genetic code in Chapter 11.
Connecting and integrating transmission and molecular genetics helps students understand how today’s geneticists think.

1 The Molecular Basis of Heredity, Variation, and Evolution
2 Transmission Genetics
3 Cell Division and Chromosome Heredity
4 Gene Interaction
5 Genetic Linkage and Mapping in Eukaryotes
6 Genetic Analysis and Mapping in Bacteria and Bacteriophage
7 DNA Structure and Replication
8 Molecular Biology of Transcription and RNA Processing
9 The Molecular Biology of Translation
10 The Integration of Genetic Approaches: Understanding Sickle Cell Disease
11 Chromosome Structure
12 Gene Mutation, DNA Repair, and Homologous Recombination
13 Chromosome Aberrations and Transposition
14 Regulation of Gene Expression in Bacteria and Bacteriophage
15 Regulation of Gene Expression in Eukaryotes
16 Forward Genetics and Recombinant DNA Technology
17 Applications of Recombinant DNA Technology and Reverse Genetics
18 Genomics: Genetics from a Whole-Genome Perspective
19 Cytoplasmic Inheritance and the Evolution of Organelle Genomes
20 Developmental Genetics
21 Genetic Analysis of Quantitative Traits
22 Population Genetics and Evolution

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About the Author(s)

Mark F. Sanders has been a faculty member in the Department of Molecular and Cellular Biology at the University of California, Davis for 27 years. In that time, he has taught more than 120 genetics courses to more than 30,000 undergraduate students. Specializing in teaching the genetics course for which this book is written, Dr. Sanders also teaches a genetics laboratory course, an advanced human genetics course for biology majors, and a human heredity course for non-science majors. His teaching experience also includes introductory biology, and courses in population genetics and evolution.

Dr. Sanders received his Bachelors degree in Anthropology from San Francisco State University and his Master’s and Ph.D. degrees in Biological Anthropology from the University of California, Los Angeles. Following graduation, he spent four years at the University of California, Berkeley as a post-doctoral researcher studying inherited susceptibility to human breast and ovarian cancer. At UC Berkeley he also taught his first genetics courses. Since coming to the University of California, Davis, Dr. Sanders has maintained a full-time teaching schedule and promotes academic achievement by undergraduate students in numerous ways, including as an active student advisor, through his on-going role as the director of a long-standing undergraduate student program, and by past service as the Associate Dean for Undergraduate Academic Programs in the College of Biological Sciences.

John L. Bowman is a Professor in the School of Biological Sciences at Monash University in Melbourne, Australia and an Adjunct Professor in the Department of Plant Biology at the University of California, Davis in the US. He received a B.S. in Biochemistry at the University of Illinois at Urbana-Champaign, Illinois in 1986 and a Ph.D. in Biology from the California Institute of Technology in Pasadena, California. His Ph.D. research focused on how the identities floral organs are specified in Arabidopsis (described in Chapter 20). He conducted postdoctoral research at Monash University on the regulation of floral development. From 1996-2006 his laboratory at UC Davis focused on the developmental genetics of plant development, focusing on how leaves are patterned. From 2006-2011 he was a Federation Fellow at Monash University where his laboratory is studying land plant evolution using a developmental genetics approach. At UC Davis he taught genetics, 'from Mendel to cancer', to undergraduate students, and continues to teach in genetics courses at Monash University.